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Molecules That Read Grooving on DNA in a Minor Way

Posted by Jim Clark on 16th April in amino acid

For several years now, chemists and biologists have been intrigued with DNA “antisense” technology. For example, chemists have designed modified RNAs which, through complementary base-pairing, can target specific regions of viral RNA. Such molecules are of interest as potential antiviral drugs. Similarly, it is possible to design oligonucleotides that are complementary to a target region [...]

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